Bowel Cancer Australia recently announced a team led by Professor Michael Samuel as the successful applicant for a three-year $600k early-onset bowel cancer research project through the 2023 round of Cancer Australia’s Priority-driven Collaborative Cancer Research Scheme (PdCCRS).
According to Bowel Cancer Australia, bowel cancer in the under fifties is trending upward, with 1-in-9 new bowel cancer cases now occurring in people under age 50, and presentation with metastatic disease more frequent in this demographic. Rates in the over fifties have stabilised or are declining.
Rho-associated kinase or ROCK, is an enzyme (protein) found in everyone, and it controls the shape and movement of cells within the body.
The way in which cancer cells communicate with normal cells in their environment via ROCK has been discovered to drive disease progression (invasion, metastasis, and recurrence). This understanding has revealed that blocking cancers from hijacking normal cells in this way could be a new way to target the disease.
Professor Samuel of the Centre for Cancer Biology (an alliance between the University of South Australia and SA Pathology) and the Basil Hetzel Institute for Translational Health Research will investigate ROCK-induced early-onset bowel cancer progression.
“People diagnosed with early-onset bowel cancer have a 50% chance that their cancer will recur or spread to other organs following initial intervention (e.g. surgery to remove the primary cancer), compared to around 30% in people diagnosed with late-onset bowel cancer,” says Professor Samuel.
“We have evidence that ROCK activity in bowel cancers drives this process by influencing how cancers communicate with their environment. Our project will investigate how this happens. We will also study whether certain effects of ROCK activation in early-onset bowel cancers can help us predict whose cancers will recur and whose will not,” he continues.
“In a practical sense, this could help us use targeted therapies that block cancer cells from communicating with their environment, in people who are most likely to experience recurrence of their cancer. It could also help us minimise the use of debilitating chemotherapies,” he adds.
The research team, which includes clinicians from the Central Adelaide Local Health Network, will also be examining whether proteins that interact with ROCK cause early-onset bowel cancer progression, and if they do, targeting these proteins would be a way of stopping ROCK from accelerating tumour growth.
Source: Bowel Cancer Australia
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Growing impact of blood cancer on women
According to the Leukaemia Foundation, blood cancer is one of the most urgent and under-recognised women’s health issues in Australia, with three times more Australian women diagnosed with blood cancer than ovarian and cervical cancer combined (Source: AIHW, Cancer Data in Australia, 2024).
Blood cancer has also emerged as the second most common cancer diagnosed in Australian women overall – behind only breast cancer – and the leading cancer amongst girls and women under the age of 30 (Source: AIHW, Cancer Data in Australia, 2024).
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Lived experience & human-centred design in healthcare
Recognised as one of the Top 100 Women of Influence by The Australian Financial Review, Melanie Tran is a visionary leader whose work lies at the intersection of design, technology, health, disability, and education. With a focus on human-centred design, digital strategy, and service design, she leads transformative initiatives as a Manager in Design, Digital and Data at Nous Group, a global consulting firm. Her work is driven by a deep passion for using creativity and technology to solve complex social challenges.
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Sense of service and pride in uniform
This ANZAC Day 2023, Australian Health Journal releases an interview with Group Captain Kath Stein MACN, Director of Defence Force Nursing with the Royal Australian Air Force.
She talks about many masks, aside from PPE, that leadership and all nurses need to wear. Currently there is work underway on a new capability description on what a nurse brings to every level in the nursing defence structure. The advice Group Captain Stein, imparts for new recruits and those interested in joining Defence Force Nursing is to take every opportunity that arises. This is evident in her progression through her career.
