Bowel Cancer Australia recently announced a team led by Professor Michael Samuel as the successful applicant for a three-year $600k early-onset bowel cancer research project through the 2023 round of Cancer Australia’s Priority-driven Collaborative Cancer Research Scheme (PdCCRS).
According to Bowel Cancer Australia, bowel cancer in the under fifties is trending upward, with 1-in-9 new bowel cancer cases now occurring in people under age 50, and presentation with metastatic disease more frequent in this demographic. Rates in the over fifties have stabilised or are declining.
Rho-associated kinase or ROCK, is an enzyme (protein) found in everyone, and it controls the shape and movement of cells within the body.
The way in which cancer cells communicate with normal cells in their environment via ROCK has been discovered to drive disease progression (invasion, metastasis, and recurrence). This understanding has revealed that blocking cancers from hijacking normal cells in this way could be a new way to target the disease.
Professor Samuel of the Centre for Cancer Biology (an alliance between the University of South Australia and SA Pathology) and the Basil Hetzel Institute for Translational Health Research will investigate ROCK-induced early-onset bowel cancer progression.
“People diagnosed with early-onset bowel cancer have a 50% chance that their cancer will recur or spread to other organs following initial intervention (e.g. surgery to remove the primary cancer), compared to around 30% in people diagnosed with late-onset bowel cancer,” says Professor Samuel.
“We have evidence that ROCK activity in bowel cancers drives this process by influencing how cancers communicate with their environment. Our project will investigate how this happens. We will also study whether certain effects of ROCK activation in early-onset bowel cancers can help us predict whose cancers will recur and whose will not,” he continues.
“In a practical sense, this could help us use targeted therapies that block cancer cells from communicating with their environment, in people who are most likely to experience recurrence of their cancer. It could also help us minimise the use of debilitating chemotherapies,” he adds.
The research team, which includes clinicians from the Central Adelaide Local Health Network, will also be examining whether proteins that interact with ROCK cause early-onset bowel cancer progression, and if they do, targeting these proteins would be a way of stopping ROCK from accelerating tumour growth.
Source: Bowel Cancer Australia
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Intervention in hearing loss for patients
In her role as an audiologist and trainer, Lauren McNee emphasises the urgency of addressing sudden hearing loss, highlighting the time-sensitive nature of available treatment options. She advises healthcare professionals, including GPs, pharmacists, primary care nurses and specialists, to remain vigilant for subtle signs of hearing loss in their patients. Such signs may include difficulty following prescription guidelines, miscommunication during conversations, or non-verbal cues like a tilt of the head or asking for repetitions.
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More health care volunteers needed for Street Side Medics
Identifying a gap in the healthcare of vulnerable people in New South Wales, Dr Daniel Nour founded Street Side Medics in August 2020, a not-for-profit, GP-led mobile medical service for people experiencing homelessness.
Dr. Daniel Nour is a cardiology advanced trainee at Royal North Shore Hospital and the founder of Street Side Medics, a mobile medical service dedicated to providing GP-led care to individuals experiencing homelessness. The initiative started from a customised van, which serves as a medical clinic, visiting food services and shelters across New South Wales and recently Victoria. Street Side Medics offers free medical care without requiring documentation, ID, or a Medicare card.
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Entering The New Health Frontier
A new parliamentary report ‘The New Frontier: Delivering better health for all Australians’ is recommending significant reforms to the health care system to ensure Australians have better and faster access to the wave of new medicines and technologies.
The bipartisan report makes 31 recommendations to reform Australia’s system for the regulation and reimbursement with the hope that patients will receive faster access to the latest medicines and technologies.
