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ICTD: Why negative results in clinical trials matter

To mark International Clinical Trials Day 2026, Australian Health Journal commences a 4 part special series leaving up to 20th May. Through conversations with leading researchers, clinicians and trial organisations, the series highlights achievements in the year that was for clinical trials.
Negative results in a clinical trial can be extremely valuable — both scientifically and ethically. A “negative result” usually means the treatment being tested did not work better than the standard treatment, placebo, or expected outcome.

Negative results in a clinical trial can be extremely valuable — both scientifically and ethically. A “negative result” usually means the treatment being tested did not work better than the standard treatment, placebo, or expected outcome.

Closing the diagnostic gap in ovarian cancer detection

After 15 years in academia, Associate Professor Michelle Hill founded ProSeek bio to address one of the most urgent challenges in women’s health: closing the diagnostic gap in ovarian cancer.

For too long, women suspected of ovarian cancer have faced an impossible choice — undergo invasive surgery for diagnosis, only for up to 80% of those procedures to reveal no cancer, or delay intervention and risk diagnosis at a later stage when treatment options are fewer and survival outcomes are significantly worse.

In development, age specific clinical practice guidelines for early onset bowel cancer

The National Health and Medical Research Council (NHMRC) has agreed to consider for approval the Clinical Practice Guidelines for the Early Diagnosis and Management of Early-Onset Colorectal Cancer (EOCRC), to be developed by Bowel Cancer Australia in collaboration with the Australian Living Evidence Collaboration (ALEC), and funded by Bowel Cancer Australia. ALEC is led by Cochrane Australia and based in the School of Public Health and Preventive Medicine at Monash University.

Sydney North Neighbourhood Health Hubs to approach health and welfare in holistic way

Many people struggle to access the right care at the right time, leading to gaps, delays, and confusion when navigating the health system. By fostering collaboration and integration, the Wellbeing Collaborative will support a primary care system that works better together, making it easier for individuals to receive early intervention and preventative care. By working together and in partnership, Sydney North Health Network aim to create more connected, accessible, and person-centred services that address key health challenges locally, including chronic illness, mental health, aged care, alcohol and other drugs (AOD), and suicide prevention.

Evolution in consumer diagnostics with saliva based pathology

Since the COVID-19 pandemic, consumer diagnostics have rapidly advanced, with more people becoming aware of and comfortable using at-home testing. These tests provide greater convenience, control, and empowerment, allowing individuals to monitor their health without immediately consulting a healthcare professional. Recently, this shift has been particularly impactful in areas such as pregnancy testing, where saliva-based diagnostics now enable earlier and more accessible detection.

Course developed for people with intellectual disability to learn about research

Scope Australia is one of the largest not-for-profit disability service providers in Australia, supporting thousands of people with complex intellectual, physical, and multiple disabilities. 
They operate across Victoria and New South Wales across more than 425 service locations.

Scope’s research team developed a course about what research is and how to do research. Eight people with intellectual disability did the course. Five people took part in interviews to help Scope learn about the course and how to make it better.

HEALTH CARE BRIEF: Postpartum haemorrhage

Postpartum haemorrhage- Incidence rates, symptoms, risks, research & innovation

Intersection of multiple births, birth trauma and perinatal mental health

Mothers of multiples are five times more likely to experience depression and have triple the rates of anxiety compared to mothers of singletons. Danya McStein is a Clinical Team Manager at Gidget Foundation Australia, talks about mothers expecting twins showing prenatal depressive symptoms, while postpartum, facing higher risks of clinical exhaustion and postpartum depression.

Early detection & surveillance guides for pancreatic cancer

Pancreatic cancer remains one of Australia’s deadliest cancers, with five-year survival rates hovering at just 14%, with little improvement over several decades. Often called the ‘silent killer’, the disease frequently presents with minimal or vague symptoms, resulting in late diagnoses and poor outcomes. Pancare Foundation is leading the rollout of new clinical resources and surveillance guides to support healthcare professionals in identifying at-risk patients and promoting early detection.

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