Bowel Cancer Australia recently announced a team led by Professor Michael Samuel as the successful applicant for a three-year $600k early-onset bowel cancer research project through the 2023 round of Cancer Australia’s Priority-driven Collaborative Cancer Research Scheme (PdCCRS).
According to Bowel Cancer Australia, bowel cancer in the under fifties is trending upward, with 1-in-9 new bowel cancer cases now occurring in people under age 50, and presentation with metastatic disease more frequent in this demographic. Rates in the over fifties have stabilised or are declining.
Rho-associated kinase or ROCK, is an enzyme (protein) found in everyone, and it controls the shape and movement of cells within the body.
The way in which cancer cells communicate with normal cells in their environment via ROCK has been discovered to drive disease progression (invasion, metastasis, and recurrence). This understanding has revealed that blocking cancers from hijacking normal cells in this way could be a new way to target the disease.
Professor Samuel of the Centre for Cancer Biology (an alliance between the University of South Australia and SA Pathology) and the Basil Hetzel Institute for Translational Health Research will investigate ROCK-induced early-onset bowel cancer progression.
“People diagnosed with early-onset bowel cancer have a 50% chance that their cancer will recur or spread to other organs following initial intervention (e.g. surgery to remove the primary cancer), compared to around 30% in people diagnosed with late-onset bowel cancer,” says Professor Samuel.
“We have evidence that ROCK activity in bowel cancers drives this process by influencing how cancers communicate with their environment. Our project will investigate how this happens. We will also study whether certain effects of ROCK activation in early-onset bowel cancers can help us predict whose cancers will recur and whose will not,” he continues.
“In a practical sense, this could help us use targeted therapies that block cancer cells from communicating with their environment, in people who are most likely to experience recurrence of their cancer. It could also help us minimise the use of debilitating chemotherapies,” he adds.
The research team, which includes clinicians from the Central Adelaide Local Health Network, will also be examining whether proteins that interact with ROCK cause early-onset bowel cancer progression, and if they do, targeting these proteins would be a way of stopping ROCK from accelerating tumour growth.
Source: Bowel Cancer Australia
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Jack Lancaster, Evolution Surgical
Continuing the Australian Health Journal, People In Health Care series is Jack Lancaster, the CEO of Evolution Surgical, an Australian owned company established in 2014, specialising in spinal fusion implants and custom instrumentation.
Jack talks about how the company works closely with surgeons to design custom solutions manufactured to surgical requirements, and ultimately, to the benefit of the Australia patient.
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Unheard and marginalised
Earlier in 2021, a preliminary community research report was released by the Caring Futures Institute at Flinders University. The report was a co-design and co-research investigation by academics and health consumers, of the social and health exclusion factors and lived experiences of Frail and Homebound and Bedbound People (FHBP) in Australia.
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Study reveals socioeconomic barriers to children’s healthcare access
Research published in the Australian Journal of General Practice (AJGP) has revealed mental health and developmental–behavioural issues such as ADHD are the most common paediatric referrals in metropolitan general practices.
But the research also revealed children at higher risk are less likely to get the care they may need.
